Spanish monarch (1451–1504) best known as the sponsor and patron of Christopher Columbus in his ventures to the ‘New World.’ Manuscript DS, signed “Yo La Reyna [I the Queen],” one page 9 x 12, dated April 6, 1501, in old Spanish. The document presents an order to the Queen’s chamberlain, Sancho de Paredes, to pay the sum of 7,500 maravedis to Friar Juan Beato, thus completing his annual salary of 15,000 maravedis. Countersigned by the Queen’s secretary Gasper De Trizio, beneath the words, “by Command of the Queen.” In very good to fine condition, with two repaired cancellation cuts, and expected folds and wrinkles. Remarkably bright and well-preserved for having been signed over 500 years ago! Pre-certified John Reznikoff/PSA/DNA and RR Auction COA.